Of 118 cases comprising various diseases of this organ, such as abscess, hematoma, glossitis, leucoplakia, papilloma, and tuberculous ulcer, 98 were. Pdf on sep 24, 2016, manas bajpai and others published squamous cell carcinoma of tongue find, read and cite all the research. Dec 22, 2017 tongue cancer is a type of cancer that starts in the cells of the tongue, and can cause lesions or tumors on your tongue. Anatomy of oral cavity extends from skin vermilion junction of lips to junction of hard and soft palate above below it is limited to circumvallate papilla of tongue. Squamous cell carcinoma is the name for a cancer that starts in these cells. Longterm regional control after radiation therapy and neck dissection for base of tongue carcinoma. Tongue cancer is a form of cancer that begins in the cells of the tongue. This is a case of a 43yearold man who in 2014 was diagnosed with oral squamous cell carcinoma involving the tongue.
Treatment of adenoid cystic carcinoma of the mobile tongue. This commentary will focus on carcinoma of the tongue. Between august 1999 and june 2011, a total of 398 patients with squamous cell carcinoma of the tongue were treated at the department of oral and maxillofacial surgery, king edward medical university. Apr 03, 2020 squamous cell carcinoma is one of the most common types of cancer of the tongue. The symptoms vary depending upon the location of the tumor and the stage of the disease. Progression free survival and loco regional control was better in chemo radiotherapy group. Bryan bell, in oral, head and neck oncology and reconstructive surgery, 2018. Clear cell carcinoma ccc also known as clear cell adenocarcinoma and hyalinizing clear cell carcinomahccc is one of the rarest tumors of the minor salivary glands and infrequently occurs at the base of the tongue. A biopsy was carried out and histopathological analysis confirmed as diagnosis of adenoid cystic carcinoma. The margin of the excised tissue was found to be free of tumor but there was. Objective to determine the effect of the margin sampling technique on local recurrence lr in patients with stage i or ii oral tongue scc. Surveillance computed tomography in december 2016 showed a cardiac lesion in the left. Computed tomography ct of the head and neck enhanced scanning revealed an illdefined high density mass. Statistics on tongue cancer squamous cell carcinoma of the tongue it is relatively common, with 3% of all malignancies arising within the oral cavity.
Like other cancers, it happens when cells divide out of control and form a growth, or tumor. Squamous cell carcinoma of the base of tongue springerlink. Factors that may influence its development include smoking. Carcinoma of the tongue is a type of skin cancer that appears on some part of the tongue. Patient was operated for segmental glossectomy, modified radical neck dissection of left side and primary closure by dr. Like all environmental factors, the rate at which cancer will develop is dependent on the dose, frequency and method of application of the carcinogen the substance that is causing the cancer. This report describes a complete response to a chemoradiotherapy regimen in a child with an advanced and unresectable squamous cell carcinoma of the tongue. Squamous cells are the flat, skin like cells that cover the lining of the mouth, nose, larynx, thyroid and throat. We describe a case of a 43yearold man patient with numbness and growth in the tongue for 1 month duration. Unlike small cell carcinoma lung, extra pulmonary small cell carcinoma is uncommon and in base of tongue, it is extremely rare. Without early treatment, the cancer may spread to other parts of the body, creating a potential medical crisis. Squamous cell carcinoma of tongue arc journal of dental science page 3 squamous cell carcinoma is the most common malignancy affecting the oral cavity characterized by a. Tongue cancers are oral cancers that are differentiated by their location in the mouth and on the tongue. Squamous cell carcinoma of the tongue with metastasis to.
This study aimed to determine etiologic factors for tongue cancer with agesex matched casecontrol data. Modern surgical management of tongue carcinoma a clinical. Background carcinoma of the tongue is the most common intraoral malignancy in western countries. In 52 patients with tongue squamous cell carcinoma confirmed by pathology, there were 34 males and 18 females age, 2278 years. Our patient data show that microrna424 alterations are a marker of field cancerisation specific for tongue tumourigenesis, which also could have a role in development of tongue squamous cell. Adenosquamous carcinoma is a rare distinct clinicopathological entity characterized histopathologically by components of both squamous cell carcinoma and adenocarcinoma. Squamous cell carcinoma of the tongue has tobacco smoking and alcohol ingestion as major risk factors and spans two regions. Computed tomography ct of the head and neck enhanced scanning revealed an. Niacinamide, by lowering free fatty acids and regulating the redox. Ct is optimal in detection of cortical bone invasion, which appears as an interruption or erosion of the peripheral hyperattenuating rim. Oral cavity malignancies account for 20 per 100,000 population in india, out of which carcinoma tongue has a 4.
It is the eighthleading cause of cancerrelated deaths in the united states leading to approximately 8000 deaths per year. Several types of cancer can affect the tongue, but tongue cancer most often begins in the thin, flat squamous cells that line the surface of the tongue. Rapidly growing squamous cell carcinoma of the tongue. Squamous cell carcinoma, epidermoid carcinoma, tongue. Materials and methods 47 patients with carcinoma of the. City of hope comprehensive cancer center thomas mccaffrey, md, phd. Tongue cancer is a type of cancer that starts in the cells of the tongue, and can cause lesions or tumors on your tongue.
Fortunately, if detected early, these malignancies may have a more favorable prognosis. Clinical outcomes for t 12 n 01 oral tongue cancer. Symptoms of carcinoma of the tongue may include abnormally colored patches of skin on the tongue, a lump or sore that will not go away, or difficulty swallowing. This tumor has tobacco smoking and alcohol ingestion as major risk factors. Squamous cell carcinoma of the base of tongue is known to have a poor clinical prognosis that is primarily attributable to such tumors usually presenting at an advanced stage. Tongue carcinoma free download as powerpoint presentation. However, wide variation exists in the margin sampling technique. If the cancer is located towards the rear third of the tongue, it is known as a squamous cell cancer at the base of the tongue. Pdf squamous cell carcinoma of tongue researchgate. Aug 18, 2019 oscc is the most common carcinoma affecting the oral cavity and comprises over 90% of all oral tumours 9,26, with the tongue as one of the most frequent sites of presentation. T4 oral cavity tumor invades adjacent structures through cortical bone, into deep. Petct in the diagnosis and staging of tongue squamous cell carcinoma. Despite advances in treatment, the survival of patients with sccot has not significantly improved over the past several decades.
Most tongue base tumors arise from the mucosa and are squamous cell carcinoma scc. Tongue cancer nord national organization for rare disorders. Squamous cell carcinoma of tongue in a 19yearold female. Regarding the oral cavity, few studies have evaluated the otscc of the anterior two thirds of the tongue, especially among nonsmokers and nondrinkers 2,11. Nccn clinical practice guidelines in oncology nccn. She received hyperfractionated external beam radiotherapy total 74. Of the epithelioid type, carcinoma of the tongue is much more frequent than is commonly supposed. Clinical outcomes for t 12 n 01 oral tongue cancer patients.
Thus, in cancer of the tongue, mr imaging should be performed first. Although ultrasound alone has limited value in staging base of tongue carcinoma, ultrasoundguided fna is a valuable tool in characterizing the cervical lymphatics. Introduction squamous cell carcinoma scc of the tongue is the most frequent intra oral head and neck cancer. Pdf in 2018, it is estimated that about 51, 540 new cases of oral cavity and pharyngeal cancer will. In cancer of the floor of the mouth, both mr imaging and ct should be performed in the initial workup, especially in those cases in which there is a clinical doubt. If tumor extension to the mandible is suspected due to clinical or mr imaging findings, ct should be added.
Metastasis of squamous cell carcinoma of the oral tongue. The patient reported a longterm smoking and drinking habit. Dec 21, 2018 home medterms medical dictionary az list carcinoma of the tongue definition medical definition of carcinoma of the tongue medical author. Importance positive margins are associated with poor prognosis among patients with oral tongue squamous cell carcinoma scc. May 27, 2010 the aim of this study was to assess the results of curative surgery with and without radiotherapy in patients with t12n01 oral tongue squamous cell carcinoma oscc and to evaluate survival and prognostic factors. The aim of this study was to assess the results of curative surgery with and without radiotherapy in patients with t 12 n 01 oral tongue squamous cell carcinoma oscc and to evaluate survival and prognostic factors methods. These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts.
About tongue cancer tongue cancer cancer research uk. In the mouth, it most commonly starts as a painless white patch, that thickens, develops red patches, an ulcer, and continues to grow. Oral cavity and head and neck cancer occurs most often between the fifth and sixth decade of life and. Medical professionals treat this cancer with radiation, chemotherapy, and surgery. Sep 29, 2011 in our study radial forearm free flap was most frequently performed almost 25% as compared to other free flaps with survival rate of 97%. Squamous cell carcinomas sccs, also known as epidermoid carcinomas, comprise a number of different types of cancer that result from squamous cells. The cause of the condition is unknown, but genetic mutations may be involved. Our patient data show that microrna424 alterations are a marker of field cancerisation specific for tongue tumourigenesis, which also could have a. The early detection of oral cancer is particularly important, as the stage of oral cancer at the time of the diagnosis is the most critical factor determining the fiveyear. Oscc is the most common carcinoma affecting the oral cavity and comprises over 90% of all oral tumours 9,26, with the tongue as one of the most frequent sites of presentation.
Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys like other types of cancer, carcinomas are abnormal cells that. The larynx is the most frequent site of adenosquamous carcinoma in the head and neck region, and the tongue is a relatively rare site 26. Sep 28, 2016 squamous cell carcinoma of left lateral border of tongue. Case comprehensive cancer center university hospitals seidman cancer center and cleveland clinic taussig cancer institute william m. Free flap transfer reconstruction in managing tongue. He underwent extensive surgery that involved right tongue cancer resection and reconstruction with a free flap graft from his right forearm. This type of carcinoma is described in a variety of sites, including lung, pancreas, and uterine cervix, while the head and neck region is a relatively rare origin for this type of tumor. Squamous cell carcinoma scc of the oral tongue in patients less than 40 years old is a rare condition. Management of squamous cell carcinoma of the oral tongue.
Squamous cell carcinoma scc of tongue is a common malignant tumor that typically affects elderly men and women. Oral squamous cell carcinoma is a disease of environmental factors, the greatest of which is tobacco. The most common type of tongue cancer is squamous cell carcinoma scc. Surveillance computed tomography in december 2016 showed a.
Squamous cell carcinoma of the oral tongue sccot is one of the most prevalent tumors of the head and neck region. Andrew of glasgow presents some very surprising statistics relative to epithelioma of the tongue. Oral tongue cancer requires a multidisciplinary approach to treat it that includes a surgical oncologist. A 2007 metaanalysis of 17 articles and 25 data sets comparing various. The case was confirmed as a squamous cell carcinoma of the tongue.
Tongue cancer is more common than all forms of oral cavity cancer except those of the lip and occurs with increasing age. Stage 4 squamous cell carcinoma of the tongue in a child. Treatment of adenoid cystic carcinoma of the mobile tongue w. If the cancer is on the forward portion of the tongue, it is known as a squamous cell cancer of the oral tongue. The gingivae, palate, retromolar area and the buccal and labial mucosa are oral sites less frequently affected 7. Carcinoma of tongue, lymph nodes, glossectomy commandos operation. An 8yearold girl had stage 4 squamous cell carcinoma of the tongue t4n2m0, causing severe trismus and dysphagia. Discussion in oral health started by hdd, aug 14, 2014. Squamous cell carcinoma tongue radiology reference. The type of cells involved in your tongue cancer helps determine your prognosis and treatment. Original article ffdg pet ct in diagnosis and staging of. Materials and methods 47 patients with carcinoma of the tongue referred to our oral medicine clinic. These tumors usually arise from the ventrolateral aspect of the mid and posterior tongue. The tongue can be a guide for different normal findingsvariants, pathological lesions, or signs for systemic diseases.
And oral cancer can be among the differentials, which can be detected early by a thorough oral exam. Oral carcinoma is fifth most common malignancy in head and neck globally. Started in 1995, this collection now contains 6769 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. The ventral surface of the tongue and the floor of the mouth are the sites most commonly affected by. Squamous cell carcinoma of left lateral border of tongue. Combined surgery and postoperative radiotherapy for carcinoma of the base of. Retrospective analysis of 86 patients with t 12 n 01 oscc who received surgery between january 2000 and december. Mar 27, 2020 when diagnosed early, carcinoma of the tongue can be easily treated in most cases before it has a chance to spread to other parts of the body. Oral cancer, also known as mouth cancer, is cancer of the lining of the lips, mouth, or upper throat. We report a case of a 65yearold previously healthy male diagnosed as extra pulmonary small cell carcinoma of tongue who presented initially with difficulty in swallowing and later, with a solitary neck lump. Management of squamous cell carcinoma of the oral tongue and.
This is one of several kinds of oral mouth cancers. Ct and mr imaging of squamous cell carcinoma of the tongue. Here, we report our successful experience in managing pregnant woman with tongue cancer, by radical resection and free flap reconstruction. If cancer is suspected, a procedure known as a biopsy may be performed by having a small piece of the suspicious tissue removed and sent to a lab to be tested for the presence of cancer cells. Oral squamous cell carcinoma scc is the most frequent cancer of the head and neck. Most frequently, treatment failure takes the form of local and regional recurrences, but as disease control in these areas. Oral squamous cell carcinoma of tongue med oral patol oral cir. Herein, a case of adenosquamous carcinoma of the tongue is described as well as the histogenesis and clinicopathological features of this type of tumor. It is more aggressive than conventional squamous cell carcinoma affecting other body regions. Incidence and mortality rates have increased in recent years, and survival has not improved. Cancer in young patients part 2 oral cancers in lowrisk subjects. These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts common types include.
Jan 15, 2019 squamous cell carcinoma scc of tongue is a common malignant tumor that typically affects elderly men and women. When on the lips, it commonly looks like a persistent crusting ulcer that does not heal, and slowly grows. Immunohistochemical analysis of aeg1mtdhlyric in tissues of 141 salivary gland carcinoma patients liao et al. European statistics indicate an incidence of around 1020 per 100 000 of. Tongue carcinoma has become a devastating cause of morbidity in this era of tobacco consumers. The symptoms of tongue cancer include a sore throat or pain when swallowing, a sore spot in. The human papillomavirus hpv can cause cancers on the base of the tongue. Objective to determine the effect of the margin sampling technique on local recurrence lr in patients with stage i or ii oral tongue scc design, setting, and participants. How pathological criteria can impact prognosis of tongue and floor. Consequently, cancer of the oral cavity has higher mortality rates 50%. Retrospective analysis of 86 patients with t12n01 oscc who received surgery between january 2000 and december 2006. Hpv also can infect your genital area and cause cervical cancer, penile cancer, and anal cancer.