Squamous cell carcinoma of tongue in a 19yearold female. She received hyperfractionated external beam radiotherapy total 74. Squamous cell carcinoma is the name for a cancer that starts in these cells. Sep 29, 2011 in our study radial forearm free flap was most frequently performed almost 25% as compared to other free flaps with survival rate of 97%. Squamous cell carcinoma of the base of tongue springerlink.
Patient was operated for segmental glossectomy, modified radical neck dissection of left side and primary closure by dr. City of hope comprehensive cancer center thomas mccaffrey, md, phd. Background carcinoma of the tongue is the most common intraoral malignancy in western countries. Nccn clinical practice guidelines in oncology nccn.
Squamous cell carcinoma of the base of tongue is known to have a poor clinical prognosis that is primarily attributable to such tumors usually presenting at an advanced stage. Anatomy of oral cavity extends from skin vermilion junction of lips to junction of hard and soft palate above below it is limited to circumvallate papilla of tongue. Factors that may influence its development include smoking. Free flap transfer reconstruction in managing tongue. Statistics on tongue cancer squamous cell carcinoma of the tongue it is relatively common, with 3% of all malignancies arising within the oral cavity. We describe a case of a 43yearold man patient with numbness and growth in the tongue for 1 month duration. Without early treatment, the cancer may spread to other parts of the body, creating a potential medical crisis. Our patient data show that microrna424 alterations are a marker of field cancerisation specific for tongue tumourigenesis, which also could have a.
Materials and methods 47 patients with carcinoma of the. Apr 03, 2020 squamous cell carcinoma is one of the most common types of cancer of the tongue. The symptoms vary depending upon the location of the tumor and the stage of the disease. The case was confirmed as a squamous cell carcinoma of the tongue. Squamous cell carcinoma of the tongue with metastasis to. Computed tomography ct of the head and neck enhanced scanning revealed an illdefined high density mass. Treatment of adenoid cystic carcinoma of the mobile tongue. Clear cell carcinoma ccc also known as clear cell adenocarcinoma and hyalinizing clear cell carcinomahccc is one of the rarest tumors of the minor salivary glands and infrequently occurs at the base of the tongue. The cause of the condition is unknown, but genetic mutations may be involved. Regarding the oral cavity, few studies have evaluated the otscc of the anterior two thirds of the tongue, especially among nonsmokers and nondrinkers 2,11. Of 118 cases comprising various diseases of this organ, such as abscess, hematoma, glossitis, leucoplakia, papilloma, and tuberculous ulcer, 98 were. Mar 27, 2020 when diagnosed early, carcinoma of the tongue can be easily treated in most cases before it has a chance to spread to other parts of the body. Thus, in cancer of the tongue, mr imaging should be performed first. The type of cells involved in your tongue cancer helps determine your prognosis and treatment.
Our patient data show that microrna424 alterations are a marker of field cancerisation specific for tongue tumourigenesis, which also could have a role in development of tongue squamous cell. Adenosquamous carcinoma is a rare distinct clinicopathological entity characterized histopathologically by components of both squamous cell carcinoma and adenocarcinoma. Rapidly growing squamous cell carcinoma of the tongue. The margin of the excised tissue was found to be free of tumor but there was. This commentary will focus on carcinoma of the tongue. Dec 21, 2018 home medterms medical dictionary az list carcinoma of the tongue definition medical definition of carcinoma of the tongue medical author. Objective to determine the effect of the margin sampling technique on local recurrence lr in patients with stage i or ii oral tongue scc. This is a case of a 43yearold man who in 2014 was diagnosed with oral squamous cell carcinoma involving the tongue. However, wide variation exists in the margin sampling technique. Pdf in 2018, it is estimated that about 51, 540 new cases of oral cavity and pharyngeal cancer will. Like other cancers, it happens when cells divide out of control and form a growth, or tumor.
Dec 22, 2017 tongue cancer is a type of cancer that starts in the cells of the tongue, and can cause lesions or tumors on your tongue. Progression free survival and loco regional control was better in chemo radiotherapy group. Symptoms of carcinoma of the tongue may include abnormally colored patches of skin on the tongue, a lump or sore that will not go away, or difficulty swallowing. The gingivae, palate, retromolar area and the buccal and labial mucosa are oral sites less frequently affected 7. Pdf on sep 24, 2016, manas bajpai and others published squamous cell carcinoma of tongue find, read and cite all the research. Sep 28, 2016 squamous cell carcinoma of left lateral border of tongue. Fortunately, if detected early, these malignancies may have a more favorable prognosis. If the cancer is located towards the rear third of the tongue, it is known as a squamous cell cancer at the base of the tongue. Tongue cancer is a form of cancer that begins in the cells of the tongue. Squamous cell carcinomas sccs, also known as epidermoid carcinomas, comprise a number of different types of cancer that result from squamous cells. This study aimed to determine etiologic factors for tongue cancer with agesex matched casecontrol data.
In cancer of the floor of the mouth, both mr imaging and ct should be performed in the initial workup, especially in those cases in which there is a clinical doubt. Carcinoma of the tongue is a type of skin cancer that appears on some part of the tongue. Niacinamide, by lowering free fatty acids and regulating the redox. Started in 1995, this collection now contains 6769 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. Tongue cancer nord national organization for rare disorders. Despite advances in treatment, the survival of patients with sccot has not significantly improved over the past several decades. Oral cavity malignancies account for 20 per 100,000 population in india, out of which carcinoma tongue has a 4. Computed tomography ct of the head and neck enhanced scanning revealed an. This report describes a complete response to a chemoradiotherapy regimen in a child with an advanced and unresectable squamous cell carcinoma of the tongue.
The human papillomavirus hpv can cause cancers on the base of the tongue. Retrospective analysis of 86 patients with t12n01 oscc who received surgery between january 2000 and december 2006. Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys like other types of cancer, carcinomas are abnormal cells that. When on the lips, it commonly looks like a persistent crusting ulcer that does not heal, and slowly grows. These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts common types include. The early detection of oral cancer is particularly important, as the stage of oral cancer at the time of the diagnosis is the most critical factor determining the fiveyear. Discussion in oral health started by hdd, aug 14, 2014. In fact, free illness time is lower in men and higher in those cases with minimal or no keratinization. An 8yearold girl had stage 4 squamous cell carcinoma of the tongue t4n2m0, causing severe trismus and dysphagia.
Oral squamous cell carcinoma of tongue med oral patol oral cir. The tongue can be a guide for different normal findingsvariants, pathological lesions, or signs for systemic diseases. Squamous cell carcinoma scc of tongue is a common malignant tumor that typically affects elderly men and women. Andrew of glasgow presents some very surprising statistics relative to epithelioma of the tongue.
Retrospective analysis of 86 patients with t 12 n 01 oscc who received surgery between january 2000 and december. Oral carcinoma is fifth most common malignancy in head and neck globally. Original article ffdg pet ct in diagnosis and staging of. Oral squamous cell carcinoma is a disease of environmental factors, the greatest of which is tobacco. Materials and methods 47 patients with carcinoma of the tongue referred to our oral medicine clinic. The most common type of tongue cancer is squamous cell carcinoma scc. Of the epithelioid type, carcinoma of the tongue is much more frequent than is commonly supposed. Stage 4 squamous cell carcinoma of the tongue in a child. And oral cancer can be among the differentials, which can be detected early by a thorough oral exam.
Squamous cell carcinoma scc of the oral tongue in patients less than 40 years old is a rare condition. The larynx is the most frequent site of adenosquamous carcinoma in the head and neck region, and the tongue is a relatively rare site 26. Cancer in young patients part 2 oral cancers in lowrisk subjects. The patient reported a longterm smoking and drinking habit. How pathological criteria can impact prognosis of tongue and floor. Management of squamous cell carcinoma of the oral tongue. This type of carcinoma is described in a variety of sites, including lung, pancreas, and uterine cervix, while the head and neck region is a relatively rare origin for this type of tumor. In the mouth, it most commonly starts as a painless white patch, that thickens, develops red patches, an ulcer, and continues to grow. Management of squamous cell carcinoma of the oral tongue and. Case comprehensive cancer center university hospitals seidman cancer center and cleveland clinic taussig cancer institute william m.
Tongue cancer is a type of cancer that starts in the cells of the tongue, and can cause lesions or tumors on your tongue. Ct and mr imaging of squamous cell carcinoma of the tongue. Hpv also can infect your genital area and cause cervical cancer, penile cancer, and anal cancer. The symptoms of tongue cancer include a sore throat or pain when swallowing, a sore spot in. It is more aggressive than conventional squamous cell carcinoma affecting other body regions. Oral cavity and head and neck cancer occurs most often between the fifth and sixth decade of life and. Squamous cell carcinoma of the tongue has tobacco smoking and alcohol ingestion as major risk factors and spans two regions. Although ultrasound alone has limited value in staging base of tongue carcinoma, ultrasoundguided fna is a valuable tool in characterizing the cervical lymphatics.
Bryan bell, in oral, head and neck oncology and reconstructive surgery, 2018. Clinical outcomes for t 12 n 01 oral tongue cancer. Incidence and mortality rates have increased in recent years, and survival has not improved. Modern surgical management of tongue carcinoma a clinical. Petct in the diagnosis and staging of tongue squamous cell carcinoma. Pdf squamous cell carcinoma of tongue researchgate. Squamous cells are the flat, skin like cells that cover the lining of the mouth, nose, larynx, thyroid and throat. Several types of cancer can affect the tongue, but tongue cancer most often begins in the thin, flat squamous cells that line the surface of the tongue. It is the eighthleading cause of cancerrelated deaths in the united states leading to approximately 8000 deaths per year. Importance positive margins are associated with poor prognosis among patients with oral tongue squamous cell carcinoma scc. Between august 1999 and june 2011, a total of 398 patients with squamous cell carcinoma of the tongue were treated at the department of oral and maxillofacial surgery, king edward medical university. Oral tongue cancer requires a multidisciplinary approach to treat it that includes a surgical oncologist. Metastasis of squamous cell carcinoma of the oral tongue. European statistics indicate an incidence of around 1020 per 100 000 of.
These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts. If cancer is suspected, a procedure known as a biopsy may be performed by having a small piece of the suspicious tissue removed and sent to a lab to be tested for the presence of cancer cells. Immunohistochemical analysis of aeg1mtdhlyric in tissues of 141 salivary gland carcinoma patients liao et al. The ventral surface of the tongue and the floor of the mouth are the sites most commonly affected by. Surveillance computed tomography in december 2016 showed a cardiac lesion in the left. Tongue cancers are oral cancers that are differentiated by their location in the mouth and on the tongue. Clinical outcomes for t 12 n 01 oral tongue cancer patients. Combined surgery and postoperative radiotherapy for carcinoma of the base of. T4 oral cavity tumor invades adjacent structures through cortical bone, into deep. Squamous cell carcinoma, epidermoid carcinoma, tongue. May 27, 2010 the aim of this study was to assess the results of curative surgery with and without radiotherapy in patients with t12n01 oral tongue squamous cell carcinoma oscc and to evaluate survival and prognostic factors. Treatment of adenoid cystic carcinoma of the mobile tongue w.
Jan 15, 2019 squamous cell carcinoma scc of tongue is a common malignant tumor that typically affects elderly men and women. A 2007 metaanalysis of 17 articles and 25 data sets comparing various. Oral squamous cell carcinoma scc is the most frequent cancer of the head and neck. Surveillance computed tomography in december 2016 showed a. Squamous cell carcinoma of tongue arc journal of dental science page 3 squamous cell carcinoma is the most common malignancy affecting the oral cavity characterized by a. Introduction squamous cell carcinoma scc of the tongue is the most frequent intra oral head and neck cancer. Herein, a case of adenosquamous carcinoma of the tongue is described as well as the histogenesis and clinicopathological features of this type of tumor. If the cancer is on the forward portion of the tongue, it is known as a squamous cell cancer of the oral tongue. About tongue cancer tongue cancer cancer research uk. Longterm regional control after radiation therapy and neck dissection for base of tongue carcinoma. Here, we report our successful experience in managing pregnant woman with tongue cancer, by radical resection and free flap reconstruction. Squamous cell carcinoma tongue radiology reference. Squamous cell carcinoma of the oral tongue sccot is one of the most prevalent tumors of the head and neck region.
Objective to determine the effect of the margin sampling technique on local recurrence lr in patients with stage i or ii oral tongue scc design, setting, and participants. He underwent extensive surgery that involved right tongue cancer resection and reconstruction with a free flap graft from his right forearm. Oscc is the most common carcinoma affecting the oral cavity and comprises over 90% of all oral tumours 9,26, with the tongue as one of the most frequent sites of presentation. This tumor has tobacco smoking and alcohol ingestion as major risk factors.
This is one of several kinds of oral mouth cancers. Medical professionals treat this cancer with radiation, chemotherapy, and surgery. Squamous cell carcinoma of left lateral border of tongue. If tumor extension to the mandible is suspected due to clinical or mr imaging findings, ct should be added.
Most tongue base tumors arise from the mucosa and are squamous cell carcinoma scc. In 52 patients with tongue squamous cell carcinoma confirmed by pathology, there were 34 males and 18 females age, 2278 years. Ct is optimal in detection of cortical bone invasion, which appears as an interruption or erosion of the peripheral hyperattenuating rim. Like all environmental factors, the rate at which cancer will develop is dependent on the dose, frequency and method of application of the carcinogen the substance that is causing the cancer.
Consequently, cancer of the oral cavity has higher mortality rates 50%. Tongue cancer is more common than all forms of oral cavity cancer except those of the lip and occurs with increasing age. Unlike small cell carcinoma lung, extra pulmonary small cell carcinoma is uncommon and in base of tongue, it is extremely rare. Tongue carcinoma free download as powerpoint presentation. Tongue carcinoma has become a devastating cause of morbidity in this era of tobacco consumers. These tumors usually arise from the ventrolateral aspect of the mid and posterior tongue. The aim of this study was to assess the results of curative surgery with and without radiotherapy in patients with t 12 n 01 oral tongue squamous cell carcinoma oscc and to evaluate survival and prognostic factors methods. We report a case of a 65yearold previously healthy male diagnosed as extra pulmonary small cell carcinoma of tongue who presented initially with difficulty in swallowing and later, with a solitary neck lump.